Effect of Ketotifen on some reproductive hormones, spermatogenesis and immune parameters in male rats

Mast cells in inflammation, fibrosis and hypersensitivity involved. Ketotifen is a member of allergy medication that reduces inflammation. The purpose of this study was to evaluate the effect of Ketotifen on some reproductive hormones, spermatogenesis, and immune parameters in male rats. A total of 75male mice of Balb / C were selected and randomly divided into15 groups and kept in the five cages. Mice were exposed for 30 days to the influence of Ketotifen. The experimental groups were consisted of a control group (receiving Ketotifen), treatment 1 (10 mL of Ketotifen), treatment 2 (30 mL of Ketotifen), treatment 3 (50 mL of Ketotifen), respectively. After 30 days, the mice were collected and serum levels of testosterone, free testosterone, FSH, LH, ABP, prolactin, leptin, TNFα, IgE, interleukin-1, cholesterol, TG, HDL, LDL, AST, ALT were investigated. Parallel to that outlines the operations conducted and testes were examined histologically. SAS software for statistical analysis and the comparison between the data of Duncan test was used to compare the means. Ketotifen caused significant increase in the levels of testosterone and free testosterone. Serum concentrations of LH and ABP in treatment 2 were significantly increased compared to controls. Prolactin in treatment 2 was significantly decreased. Concentrations of leptin, TNFα and IL were significant. The results of the testes showed that Ketotifen in the treatment 2 increase the cell's stage of spermatogenesis. Ketotifen in treatment 2 had positive effects on reproduction, sperm and immune parameters in male mice.